Protein interactions with small molecules. Relationships between stoichiometric binding constants, site binding constants, and empirical binding parameters.
نویسندگان
چکیده
منابع مشابه
Correlation between binding rate constants and individual information of E. coli Fis binding sites
Individual protein binding sites on DNA can be measured in bits of information. This information is related to the free energy of binding by the second law of thermodynamics, but binding kinetics appear to be inaccessible from sequence information since the relative contributions of the on- and off-rates to the binding constant, and hence the free energy, are unknown. However, the on-rate could...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1975
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)41586-x